#5781 DRUG-INDUCED ACUTE INTERSTITIAL NEPHRITIS (D-AIN): HOW TO IDENTIFY THE RESPONSIBLE DRUG?

Abstract Background and Aims The mainstay of D-AIN treatment is the removal responsible drug. However, it not always easy to identify culprit drug as this entity mainly affects elderly patients on multiple medications, they rarely associate systemic symptoms (rash, fever), timeline regarding diagnosis associated clear. Therefore, are delayed, making full renal function recovery less likely. lymphocyte transformation test (LTT) has demonstrated be useful in identification involved other hypersensitivity-mediated T diseases such Stevens-Johnson Syndrome or Dress Syndrome. For reason, we wonder if could relevant identifying D-AIN. aim study LTT with clinical histological Method We have conducted a retrospective observational which collected data from 2019 2022 our electronic databases. Results: registered 9 cases diagnosed confirmation whom had been performed. 22.2% these were men. mean age was 48.1 years (standard deviation 15.8). None them previous chronic kidney disease (CKD). Mean peak creatinine at 4.66 mg/dl 1.95). Regarding typical D-AIN, three (33%) presented fever none suffered rash. 6 sterile pyuria (66%). All received steroid treatment. Concerning results, 7 positive for one drugs patient taking, 2 negative. Among cases, identified 1 case beta lactams (piperacillin), PPIs (omeprazole), metamizole, paracetamol, eslicarbazepine NSAIDs (dexketoprofen), while negative suspected taking any Conclusion may especially medications included some great importance like immunotherapy (typical cause D-AIN) oncological treatments. In expected that taken difficult history or, situations, hapten damage might metabolite itself, cannot detected by test.